Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease characterized by
chronic and relapsing manifestations. It is noteworthy that the prevalence of IBD is gradually …

Long-term exposure to adverse life events that provoke acute or chronic psychological
stress (hereinafter “stress”) can negatively affect physical health and even increase …

Diarrhea-predominant irritable bowel syndrome (IBS-D), a globally prevalent functional
gastrointestinal (GI) disorder, is associated with elevated serotonin that increases gut …

GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of
growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy …

The gastrointestinal tract is the main target of cadmium toxicity. However, whether
Akkermansia muciniphila (A. muciniphila), which has been reported to be the next …

Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity (VH) associated
with abnormal serotonin/5-hydroxytryptamine (5-HT) metabolism and neurotrophin …

Understanding the molecular mechanisms regulating tumor dissemination and therapeutic
resistance is of central importance for effective cancer therapies. Here, we report that nerve …

The incidence of peripheral nerve injury (PNI) is high worldwide, and a poor prognosis is
common. Surgical closure and repair of the affected area are crucial to ensure the effective …

Human intestinal organoids are an ideal model system for studying gastrointestinal
physiology and immunopathology. Altered physiology and mucosal immune response are …

Early life stress can considerably interfere in gut microbiome formation and nervous system
development. Specific probiotic strains have been proved to exert anti-stress effects by …