[HTML][HTML] Age-related hearing loss: sensory and neural etiology and their interdependence
KL Elliott, B Fritzsch, EN Yamoah… - Frontiers in aging …, 2022 - frontiersin.org
Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …
[HTML][HTML] The role of BDNF as a biomarker in cognitive and sensory neurodegeneration
A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …
system and in sensory structures including olfactory and auditory systems. Many studies …
Restoration of auditory evoked responses by human ES-cell-derived otic progenitors
W Chen, N Jongkamonwiwat, L Abbas, SJ Eshtan… - Nature, 2012 - nature.com
Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of
the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms …
the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms …
Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
V Matei, S Pauley, S Kaing, D Rowitch… - Developmental …, 2005 - Wiley Online Library
We investigated whether co‐expression of Neurog1 and Atoh1 in common neurosensory
precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal …
precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal …
[HTML][HTML] Differential distribution of stem cells in the auditory and vestibular organs of the inner ear
K Oshima, CM Grimm, CE Corrales, P Senn… - Journal of the …, 2007 - Springer
The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …
Engraftment and differentiation of embryonic stem cell–derived neural progenitor cells in the cochlear nerve trunk: Growth of processes into the organ of corti
CE Corrales, L Pan, H Li, MC Liberman… - Journal of …, 2006 - Wiley Online Library
Hearing loss in mammals is irreversible because cochlear neurons and hair cells do not
regenerate. To determine whether we could replace neurons lost to primary neuronal …
regenerate. To determine whether we could replace neurons lost to primary neuronal …
[HTML][HTML] Macrophages in the human cochlea: saviors or predators—a study using super-resolution immunohistochemistry
W Liu, M Molnar, C Garnham, H Benav… - Frontiers in …, 2018 - frontiersin.org
The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …
Isolation and characterization of neural crest progenitors from adult dorsal root ganglia
After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia
(DRG) is initially reduced but recovers to a normal level several months later. The …
(DRG) is initially reduced but recovers to a normal level several months later. The …
Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells
Stem cells have been demonstrated in the inner ear but they do not spontaneously divide to
replace damaged sensory cells. Mesenchymal stem cells (MSC) from bone marrow have …
replace damaged sensory cells. Mesenchymal stem cells (MSC) from bone marrow have …
Deafferentiation‐associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain‐derived …
R Glueckert, M Bitsche, JM Miller, Y Zhu… - Journal of …, 2008 - Wiley Online Library
Deafferentation of the auditory nerve from loss of sensory cells is associated with
degeneration of nerve fibers and spiral ganglion neurons (SGN). SGN survival following …
degeneration of nerve fibers and spiral ganglion neurons (SGN). SGN survival following …