Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of
the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms …

We investigated whether co‐expression of Neurog1 and Atoh1 in common neurosensory
precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal …

The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …

Hearing loss in mammals is irreversible because cochlear neurons and hair cells do not
regenerate. To determine whether we could replace neurons lost to primary neuronal …

The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …

After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia
(DRG) is initially reduced but recovers to a normal level several months later. The …

Stem cells have been demonstrated in the inner ear but they do not spontaneously divide to
replace damaged sensory cells. Mesenchymal stem cells (MSC) from bone marrow have …

Deafferentation of the auditory nerve from loss of sensory cells is associated with
degeneration of nerve fibers and spiral ganglion neurons (SGN). SGN survival following …