AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …

Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and
extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death …

Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis
contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for …

Ulcerative colitis (UC) is a chronic, idiopathic relapsing inflammatory bowel disease.
Honokiol is a major active component of the traditional Chinese medicinal herb Magnolia …

As an essential part of programmed cell death, pyroptosis is an inflammatory response that
is elicited upon infection by intracellular pathogens. Metabolic diseases, atherosclerosis and …

As a disease caused by an impaired intestinal epithelial barrier, imbalanced flora, immune
imbalance and genetic susceptibility, ulcerative colitis (UC) is becoming a health threat for …

Background & Aims Core 1–and core 3–derived mucin-type O-linked oligosaccharides (O-
glycans) are major components of the colonic mucus layer. Defective forms of colonic O …

The characteristic feature of healthy living organisms is the preservation of homeostasis.
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …