It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

The primary function of the bronchial epithelium is to act as a defensive barrier aiding the
maintenance of normal airway function. Bronchial epithelial cells (BEC) form the interface …

Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling
that are involved in neuronal development, cellular differentiation, cell migration, cancer …

After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors,
roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3, 5-di-chloropyrid-4-yl]-benzamide) …

Mucin over-production is one of the hallmarks of chronic airway diseases such as chronic
obstructive pulmonary disease, asthma, and cystic fibrosis. NF-κB activation in airway …

Mucus production is a primary defense mechanism for maintaining lung health. However,
the overproduction of mucin (the chief glycoprotein component of mucus) is a common …

Mucins are important components that exert a variety of functions in cell-cell interaction,
epidermal growth factor receptor signaling, and airways protection. In the conducting …