The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
Spin hyperpolarization in modern magnetic resonance
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …
disciplines and in various practical applications, with medical magnetic resonance imaging …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
[HTML][HTML] mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
Self-assembled mRNA vaccines
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
[HTML][HTML] Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines
After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP)
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …
From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …
curtailing pandemic spread of emerging pathogens to which a population has limited …
[HTML][HTML] Opportunities and challenges in the delivery of mRNA-based vaccines
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
Strategies for non-viral vectors targeting organs beyond the liver
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
Nanostructured particles assembled from natural building blocks for advanced therapies
Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …
regulation, specific organ and cell targeting, and/or photon energy conversion have …