Action selection is a capital feature of cognition that guides behavior in processes that range
from motor patterns to executive functions. Here, the ongoing actions need to be monitored …

As a powerful noninvasive imaging technology, positron emission tomography (PET) has
been playing an important role in disease theranostics and drug discovery. The successful …

There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical
models and human in vivo and post mortem studies. Understanding the consequences of …

Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs
early and is strongly related to functional deficits. Objective In this longitudinal observational …

Background Lack of early molecular biomarkers in sporadic behavioral variants of
frontotemporal dementia (bvFTD) and its clinical overlap with primary psychiatric disorders …

Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle
glycoprotein 2 A (SV2A) enables quantification of synaptic density in the living human brain …

Synapses are integral for healthy brain function and are becoming increasingly recognized
as key structures in the early stages of brain disease. Understanding the pathological …

Abstract Background/Objective The corticobasal syndrome (CBS) is a complex asymmetric
movement disorder, with cognitive impairment. Although commonly associated with the …

This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a
biomarker for synaptic integrity using Positron Emission Tomography (PET) in …

Abstract Background 18F-FDG brain PET is clinically used for differential diagnosis in
cognitive dysfunction of unclear etiology and for exclusion of a neurodegenerative cause in …