The dynamics of single-molecule DNA in flow

ESG Shaqfeh - Journal of Non-Newtonian Fluid Mechanics, 2005 - Elsevier
Within the last decade, fluorescence microscopy of single molecules of DNA in a plethora of
flow fields has allowed an unprecedented examination of the dynamics of polymers in flow …

Cellular strategies for regulating DNA supercoiling: a single-molecule perspective

DA Koster, A Crut, S Shuman, MA Bjornsti, NH Dekker - Cell, 2010 - cell.com
Entangling and twisting of cellular DNA (ie, supercoiling) are problems inherent to the
helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication …

Statistical topology of closed curves: Some applications in polymer physics

E Orlandini, SG Whittington - Reviews of modern physics, 2007 - APS
Topological entanglement in polymers and biopolymers is a topic that involves different
fields of science such as chemistry, biology, physics, and mathematics. One of the main …

Fluctuations, Dynamics, and the Stretch-Coil Transition of Single Actin Filaments<? format?> in Extensional Flows

V Kantsler, RE Goldstein - Physical review letters, 2012 - APS
Semiflexible polymers subject to hydrodynamic forcing play an important role in cytoskeletal
motions in the cell, particularly when filaments guide molecular motors whose motions …

Collective dynamics effect transient subdiffusion of inert tracers in flexible gel networks

A Godec, M Bauer, R Metzler - New journal of physics, 2014 - iopscience.iop.org
Based on extensive Brownian dynamics simulations we study the thermal motion of a tracer
bead in a cross-linked, flexible gel in the limit when the tracer particle size is comparable to …

Semiflexible Chain Networks Formed via Self-Assembly of -Hairpin Molecules

B Ozbas, K Rajagopal, JP Schneider, DJ Pochan - Physical review letters, 2004 - APS
We report experimental results from a de novo designed oligopeptide that intermolecularly
self-assembles into rigid hydrogel networks after an intramolecular folding event …

Fast dynamics of supercoiled DNA revealed by single-molecule experiments

A Crut, DA Koster, R Seidel… - Proceedings of the …, 2007 - National Acad Sciences
The dynamics of supercoiled DNA play an important role in various cellular processes such
as transcription and replication that involve DNA supercoiling. We present experiments that …

Forced-unfolding and force-quench refolding of RNA hairpins

C Hyeon, D Thirumalai - Biophysical journal, 2006 - cell.com
Nanomanipulation of individual RNA molecules, using laser optical tweezers, has made it
possible to infer the major features of their energy landscape. Time-dependent mechanical …

A generalized bead-rod model for Brownian dynamics simulations of wormlike chains under strong confinement

J Wang, H Gao - The Journal of chemical physics, 2005 - pubs.aip.org
This paper is aimed to develop a Brownian dynamics simulation method for strongly
confined semiflexible polymers where numerical simulation plays an indispensable role in …

Two-component molecular motor driven by a GTPase cycle

A Singh, JA Soler, J Lauer, SW Grill, M Jahnel… - Nature Physics, 2023 - nature.com
ATPases are a group of enzymes that can cyclically convert the free energy of ATP
hydrolysis into mechanical work. GTPases are another class of enzymes that are …