Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry

D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

Gas chromatography/mass spectrometry in metabolic profiling of biological fluids

KK Pasikanti, PC Ho, ECY Chan - Journal of Chromatography B, 2008 - Elsevier
One of the objectives of metabonomics is to identify subtle changes in metabolite profiles
between biological systems of different physiological or pathological states. Gas …

Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry

ECY Chan, KK Pasikanti, JK Nicholson - Nature protocols, 2011 - nature.com
The role of urinary metabolic profiling in systems biology research is expanding. This is
because of the use of this technology for clinical diagnostic and mechanistic studies and for …

Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases

K Yoon, SJ Kwack, HS Kim, BM Lee - Journal of Toxicology and …, 2014 - Taylor & Francis
Endocrine-disrupting chemicals (EDC), including phthalates, bisphenol A (BPA),
phytoestrogens such as genistein and daidzein, dichlorodiphenyltrichloroethane (DDT), and …

Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus

X Li, Z Xu, X Lu, X Yang, P Yin, H Kong, Y Yu… - Analytica Chimica Acta, 2009 - Elsevier
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry
(GC× GC–TOFMS) coupled with pattern recognition methods was applied to analyze plasma …

Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers

HM Woo, KM Kim, MH Choi, BH Jung, J Lee, G Kong… - Clinica chimica acta, 2009 - Elsevier
BACKGROUND: The metabolomic approaches for mining biomarkers of women's cancers
based on gas chromatography-mass spectrometry and liquid chromatography-mass …

Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry

J Han, RM Danell, JR Patel, DR Gumerov, CO Scarlett… - Metabolomics, 2008 - Springer
With unmatched mass resolution, mass accuracy, and exceptional detection sensitivity,
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS) has the …

Metabolomics in pesticide research and development: review and future perspectives

KA Aliferis, M Chrysayi-Tokousbalides - Metabolomics, 2011 - Springer
The emerge of metabolomics within functional genomics has provided a new dimension in
the study of biological systems. In regards to the study of agroecosystems, metabolomics …

Virtual quantification of metabolites by capillary electrophoresis-electrospray ionization-mass spectrometry: predicting ionization efficiency without chemical standards

KR Chalcraft, R Lee, C Mills… - Analytical …, 2009 - ACS Publications
A major obstacle in metabolomics remains the identification and quantification of a large
fraction of unknown metabolites in complex biological samples when purified standards are …

Mass spectrometry in systems biology: an overview

X Feng, X Liu, Q Luo, BF Liu - Mass spectrometry reviews, 2008 - Wiley Online Library
As an emerging field, systems biology is currently the talk of the town, which challenges our
philosophy in comprehending biology. Instead of the reduction approach advocated in …