The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …

Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …

Simple Summary Dose and efficacy of radiation therapy are limited by the toxicity to normal
tissue adjacent to the treated tumor region. Recently, ultra-high dose rate radiotherapy …

In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy
appear to produce fewer toxicities than standard dose rates while maintaining local tumor …

While spatial dose conformity delivered to a target volume has been pushed to its practical
limits with advanced treatment planning and delivery, investigations in novel temporal dose …