Synthesis and physicochemical characterization of Zn–Al layered double hydroxides (LDHs) as a delivery system for amphotericin B: In vitro and in silico …
Leishmaniasis as a widespread neglected vector-borne protozoan disease is a major public
health concern in endemic areas due to 12 million people affected worldwide and 60,000 …
health concern in endemic areas due to 12 million people affected worldwide and 60,000 …
In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection: Powerful synergistic and …
The ongoing conventional drugs for leishmaniasis treatment are insufficient. The present
study aimed to assess 6-gingerol alone and in combination with amphotericin B on …
study aimed to assess 6-gingerol alone and in combination with amphotericin B on …
Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal …
Currently, no safe vaccine against leishmaniasis is available. So far, different control
strategies against numerous reservoir hosts and biological vectors have not been …
strategies against numerous reservoir hosts and biological vectors have not been …
Nicotinamide mitigates visceral leishmaniasis by regulating inflammatory response and enhancing lipid metabolism
Q Zhou, Z Zheng, S Yin, D Duan, X Liao, Y Xiao, J He… - Parasites & …, 2024 - Springer
Background Currently, treatment regimens for visceral leishmaniasis (VL) are limited
because of the presence of numerous adverse effects. Nicotinamide, a readily available and …
because of the presence of numerous adverse effects. Nicotinamide, a readily available and …
Antileishmanial potentials of azacitidine and along with meglumine antimoniate on Leishmania major: In silico prediction and in vitro analysis
This study aimed to investigate the in vitro and in silico antileishmanial activity of azacitidine
(AZA) on Leishmania major promastigotes and amastigotes. The in silico method was used …
(AZA) on Leishmania major promastigotes and amastigotes. The in silico method was used …
In silico and in vitro antileishmanial effects of gamma-terpinene: Multifunctional modes of action
M Nooshadokht, M Mirzaei, I Sharifi, F Sharifi… - Chemico-Biological …, 2022 - Elsevier
Introduction Leishmaniasis denotes a significant health challenge worldwide with no
ultimate treatment. The current study investigated the biological effects of gamma-terpinene …
ultimate treatment. The current study investigated the biological effects of gamma-terpinene …
Nature-derived Alkaloids as a Promising Bioactive Compound in Drug Discovery to Meet Global Leishmania Needs
Background: Natural products have been important resources for potential drug
development. Among the many classes of natural products, alkaloids have the most …
development. Among the many classes of natural products, alkaloids have the most …
Antiproliferative properties of Turmerone on Leishmania major: Modes of action confirmed by antioxidative and immunomodulatory roles
Abstract Treatment of leishmaniasis by conventional synthetic compounds has faced a
serious challenge worldwide. This study was performed to evaluate the effect and modes of …
serious challenge worldwide. This study was performed to evaluate the effect and modes of …
In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of …
Conventional therapeutic agents are no longer adequate against leishmaniasis. This
complex condition continues to have a high mortality rate and public health impact. The …
complex condition continues to have a high mortality rate and public health impact. The …
The Potential Role of Lipopeptide Biosurfactant Generated by Acinetobacter junii B6 on Leishmania Tropica: The Synergy of Lipopeptide Biosurfactant and …
An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB)
produced by Acinetobacter junii B6 affects Leishmania tropica infection and the associated …
produced by Acinetobacter junii B6 affects Leishmania tropica infection and the associated …