Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

Vascular diseases of the elderly are a topic of enormous interest in clinical practice, as they
have great epidemiological significance and lead to ever-increasing healthcare …

Dysregulation of intercellular communication is a hallmark of aging. To better quantify and
explore changes in intercellular communication, we present scDiffCom and scAgeCom …

Pericytes are mural cells of the microvasculature, recognized by their thin processes and
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …

The repair of large bone defects due to trauma, disease, and infection can be exceptionally
challenging in the elderly. Despite best clinical practice, bone regeneration within …

Aging is associated with remodelling of immune and central nervous system responses
resulting in behavioural impairments including social deficits. Growing evidence suggests …

Impaired angiogenesis is associated with cognitive decline in older adults. While exercise
has been broadly associated with increased angiogenesis, the relevant mechanisms in …

Pulmonary fibrosis (PF) is a progressive chronic lung disease characterized by excessive
deposition of extracellular matrix (ECM) and structural destruction, associated with a severe …

Background: This study aims to investigate potential markers of psoriasis and aging, and to
elucidate possible connections between these two processes. Methods: The serum samples …

Perivascular cells in the pericytic microvasculature, pericytes and CD34+ stromal
cells/telocytes (CD34+ SCs/TCs), have an important role in angiogenesis. We compare the …