Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Upon apoptotic stimuli, epithelial cells compensate the gaps left by dead cells by activating
proliferation. This has led to the proposal that dying cells signal to surrounding living cells to …

Tumors kill patients not only through well-characterized perturbations to their local
environment but also through poorly understood pathophysiological interactions with distant …

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …

There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Although cellular tumor-suppression mechanisms are widely studied, little is known about
mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in …

Cell competition is a form of cell interaction that causes the elimination of less fit cells, or
losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can …