Background Alzheimer's disease (AD) pathology begins several years before the clinical
onset. The long preclinical phase is composed of three stages according to the …

Clinical specialization is not only a force for progress, but it has also led to the fragmentation
of medical knowledge. The focus of research in the field of Alzheimer's disease (AD) is …

Alzheimers disease (AD) is the most common age-related dementia. Among its major
challenges is identifying molecular signatures characteristic for the early AD stage in …

Subjective cognitive decline (SCD), characterized by a very early and subtle cognitive
decline prior to the appearance of objective cognitive impairment, is considered to be the …

The apolipoprotein E ɛ4 allele (APOE4) is universally acknowledged as the most potent
genetic risk factor for Alzheimer's disease (AD). APOE4 promotes the initiation and …

Alzheimer's disease (AD) pathology begins decades before the onset of clinical symptoms. It
is recognized as a clinicobiological entity, being detectable in vivo independently of the …

Background: Subjective memory complaints (SMCs) are incorporated into the diagnosis of
mild cognitive impairment (MCI) and neurodegenerative dementias; however, the relative …

Background: Neuropsychological assessments are essential to define the cognitive profile
and contribute to the diagnosis of Alzheimer's disease (AD). The progress in knowledge …

Cerebrospinal fluid (CSF) β-amyloid (Aβ) is important for early diagnosis of Alzheimer's
disease (AD). However, the cohort distributions and cut-off values have large variation …

Results Amongst 40 patients with MCI, 9 (22.5%) converted to AD within 2 years of
observation. Discriminant analysis was conducted and sensitivity for MCI conversion to AD …