Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …
undergoes a series of molecular events that lead to a change in phenotype toward a …
Cell motility in cancer invasion and metastasis: insights from simple model organisms
CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
[HTML][HTML] Fucoidan structure and activity in relation to anti-cancer mechanisms
G Van Weelden, M Bobiński, K Okła, WJ Van Weelden… - Marine drugs, 2019 - mdpi.com
Fucoidan is a natural derived compound found in different species of brown algae and in
some animals, that has gained attention for its anticancer properties. However, the exact …
some animals, that has gained attention for its anticancer properties. However, the exact …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
[HTML][HTML] Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
RAS interaction with PI3K: more than just another effector pathway
E Castellano, J Downward - Genes & cancer, 2011 - journals.sagepub.com
RAS proteins are small GTPases known for their involvement in oncogenesis: around 25%
of human tumors present mutations in a member of this family. RAS operates in a complex …
of human tumors present mutations in a member of this family. RAS operates in a complex …
Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways
L Larue, A Bellacosa - Oncogene, 2005 - nature.com
Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …
[PDF][PDF] Mutant PIK3CA promotes cell growth and invasion of human cancer cells
PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations
have not been defined. To evaluate the consequences of PIK3CA alterations, the two most …
have not been defined. To evaluate the consequences of PIK3CA alterations, the two most …
Rational design and action mechanisms of chemically innovative organoselenium in cancer therapy
Organo-seleno compounds (org-Se) have been widely used in antitumor, antiviral, and
antiinflammatory therapy; antioxidation and other biological fields. As such, they have made …
antiinflammatory therapy; antioxidation and other biological fields. As such, they have made …
PKB/Akt–dependent regulation of cell motility
G Xue, BA Hemmings - Journal of the National Cancer Institute, 2013 - academic.oup.com
The prosurvival activity of phosphoinositide 3 kinase (PI3K)/Akt (also known as protein
kinase B, PKB) pathway has been investigated in great detail in human physiology and …
kinase B, PKB) pathway has been investigated in great detail in human physiology and …