Elastic fibers are the main components of the extracellular matrix of the large arterial wall.
Elastic fiber remodeling is an intricate process of synthesis and degradation of the core …

Quantifying biomechanical properties of the human vasculature could deepen our
understanding of cardiovascular diseases. Standard nonlinear regression in constitutive …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations
predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity …

Aging is a nonmodifiable risk factor for cardiovascular disease associated with arterial
stiffening and endothelial dysfunction. We hypothesized that sex differences exist in vascular …

Introduction: Aging has many effects on the cardiovascular system, including changes in
structure (aortic composition, and thus stiffening) and function (increased proximal blood …

Many genetic mutations adversely affect the structure and function of load-bearing soft
tissues, with clinical sequelae often responsible for disability or death. Parallel advances in …

Changes in vascular structure contribute to vascular events and loss of brain health. We
examined changes in cerebral arterioles at the onset of hypertension and the hypothesis …

Age-related remodelling of the arterial wall shifts the load bearing from the compliant elastin
network to the stiffer collagen fibres. While this phenomenon has been widely investigated in …

Vascular aging has a central role in the pathogenesis of cardiovascular diseases
contributing to increased mortality of older adults. There is increasing evidence that, in …