Where do we stand on fMRI in awake mice?

F Mandino, S Vujic, J Grandjean, EMR Lake - Cerebral cortex, 2024 - academic.oup.com
Imaging awake animals is quickly gaining traction in neuroscience as it offers a means to
eliminate the confounding effects of anesthesia, difficulties of inter-species translation (when …

[PDF][PDF] Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

WT Zhang, THH Chao, Y Yang, TW Wang, SH Lee… - Cell reports …, 2022 - cell.com
Fiber photometry is an emerging technique for recording fluorescent sensor activity in the
brain. However, significant hemoglobin absorption artifacts in fiber photometry data may be …

Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states

KL Turner, KW Gheres, PJ Drew - Journal of Neuroscience, 2023 - Soc Neuroscience
Arousal state affects neural activity and vascular dynamics in the cortex, with sleep
associated with large changes in the local field potential and increases in cortical blood flow …

[HTML][HTML] High-frequency neuronal signal better explains multi-phase BOLD response

Q Zhang, SR Cramer, KL Turner, T Neuberger… - Neuroimage, 2023 - Elsevier
Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit
more complex temporal dynamics than a simple monophasic response. For instance, BOLD …

[HTML][HTML] Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice

KW Gheres, HS Ünsal, X Han, Q Zhang… - Communications …, 2023 - nature.com
In the adult sensory cortex, increases in neural activity elicited by sensory stimulation usually
drive vasodilation mediated by neurovascular coupling. However, whether neurovascular …

Deriving causal relationships in resting-state functional connectivity using SSFO-based optogenetic fMRI

X Han, SR Cramer, N Zhang - Journal of neural engineering, 2022 - iopscience.iop.org
Objective. The brain network has been extensively studied as a collection of brain regions
that are functionally inter-connected. However, the study of the causal relationship in brain …

Connecting the dots between cell populations, whole-brain activity, and behavior

LN Beloate, N Zhang - Neurophotonics, 2022 - spiedigitallibrary.org
Simultaneously manipulating and monitoring both microscopic and macroscopic brain
activity in vivo and identifying the linkage to behavior are powerful tools in neuroscience …

[HTML][HTML] Rat superior colliculus encodes the transition between static and dynamic vision modes

R Gil, M Valente, N Shemesh - Nature Communications, 2024 - nature.com
The visual continuity illusion involves a shift in visual perception from static to dynamic vision
modes when the stimuli arrive at high temporal frequency, and is critical for recognizing …

[HTML][HTML] Spatio-temporally efficient coding assigns functions to hierarchical structures of the visual system

D Sihn, SP Kim - Frontiers in Computational Neuroscience, 2022 - frontiersin.org
Hierarchical structures constitute a wide array of brain areas, including the visual system.
One of the important questions regarding visual hierarchical structures is to identify …

Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest

D Cleppien, F Aedo-Jury, A Stroh - Neurophotonics, 2022 - spiedigitallibrary.org
Significance: Due to the vascular origin of the fMRI signal, the spatiotemporally precise
interpretation of the blood oxygen level-dependent (BOLD) response as brain-wide correlate …