Abstract Juglone (5-hydroxy-1, 4-naphthalene diketone) is a kind of natural
naphthoquinone, present in the roots, leaves, nut-hulls, bark and wood of walnut trees …

Quinones are plant-derived secondary metabolites that present some anti-proliferation and
anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses …

Redox signaling plays a fundamental role in maintaining cell physiological activities. A
deregulation of this balance through oxidative stress or nitrosative stress has been …

Colorectal cancer (CRC) is the third most common fatal cancer. Indomethacin, a
nonsteroidal anti‐inflammatory drug, is known to reduce the occurrence of CRC. This study …

Pancreatic cancer remains a formidable challenge due to limited treatment options and its
aggressive nature. In recent years, the naturally occurring anticancer compound juglone has …

The SKN-1/Nrf transcription factors are master regulators of oxidative stress responses and
are emerging as important determinants of longevity. We previously identified a protein …

Juglone is a metabolite produced by several species of plants, in particular Juglans nigra.
Additionally, juglone is a 1, 4-naphthoquinone that has several biological actions …

Abstract Background/Purpose Juglone, a natural compound widely found in Juglandaceae
plants, has been suggested as a potential drug candidate for treating cancer, inflammation …

Purpose: Radiation-mediated immune suppression limits efficacy and is a barrier in cancer
therapy. Radiation induces negative regulators of tumor immunity including regulatory T …

Myeloid-derived suppressor cells (MDSCs) contribute to immune activity suppression and
promote the tumor progression. Elimination of MDSCs is a promising cancer therapeutic …