Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

Dynamic control of gene expression is critical for blood stage development of malaria
parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the …

Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …

Indole compounds are involved in a range of functions in many organisms. In the human
malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are …

Due to the recent reports of growing parasite resistance to artemisinins and other
antimalarial drugs, development of new antimalarial chemotypes is an urgent priority. Here …

Malaria remains a heavy public health and socioeconomic burden in tropical and
subtropical regions. Increasing resistance against front-line treatments implies that novel …

The ubiquitin proteasome system has been proposed as a possible mechanism involved in
the multiple actions of melatonin. COP 1 (constitutive photomorphogenesis protein 1), a …

Malaria, which infects more than 300 million people annually, is a serious disease.
Epidemiological surveys indicate that of those who are affected, malaria will claim the lives …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a circadian hormone produced in
vertebrates by the pineal gland and other organs. Melatonin is believed to influence immune …