Proteins in the signaling lymphocytic activating molecule (SLAM) family play crucial roles in
regulating the immune system. CD244 (SLAMF4) is a protein in this family, and is also a …

Diabetes mellitus is a very important social issue, and its retinal complications continue to be
one of the major causes of blindness worldwide. The effect of glucose level on the …

While obesity and associated metabolic complications are linked to inflammation of white
adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local …

Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its
consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage …

A key goal of geroscience research is to identify effective interventions to extend human
healthspan, the years of healthy life. Currently, majority of the geroprotectors are found by …

Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that
excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation …

Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development
of excess body fat-related metabolic complications. Animal studies have suggested the …

Nonalcoholic fatty liver disease (NAFLD) is becoming a worldwide health problem, but no
approved medical treatment exists so far. Nuclear receptors are one of the drug targets for …

Objective Although IL-10 is generally considered as an anti-inflammatory cytokine, it was
recently shown to have detrimental effects on insulin sensitivity and fat cell metabolism in …

Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of
cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but …