Aldo‐X Bifunctional Building Blocks for the Synthesis of Heterocycles

P Ravichandiran, B Lai, Y Gu - The Chemical Record, 2017 - Wiley Online Library
Compounds containing oxygen, nitrogen, or sulfur atoms inside the rings are attracting much
attention and interest due to their biological importance. In recent years, several methods for …

The maiden comprehensive report on emerging trend towards metal free synthesis of biologically potent 2H-Chromenes

A Ghatak, A Pramanik, M Das - Tetrahedron, 2022 - Elsevier
Abstract 2H-Chromenes are crucial and immensely important pharmaceutically active
oxygenated heterocyclic compounds possess as key skeleton of verities bioactive natural …

Tyrosine kinase inhibitors

DM Goldstein - US Patent 8,673,925, 2014 - Google Patents
0 C* C. NC1= NC= Nc2c1C (C1= CC= CC= C1) CC2.[1*] C.[2*] C.[3*] C.[4*] C.[5*] C.[6*]
C.[7*] C.[Ar] Chemical compound C* C. NC1= NC= Nc2c1C (C1= CC= CC= C1) CC2.[1*] …

Cell-permeable iminocoumarine-based fluorescent dyes for mitochondria

D Guo, T Chen, D Ye, J Xu, H Jiang, K Chen… - Organic …, 2011 - ACS Publications
A class of small molecule fluorophores, 2-iminocoumarin-3-carboxamide derivatives, has
been developed by a rapid microwave-assisted process. These fluorescent probes are cell …

Direct Construction of 2-Aryliminochromenes from Arynes, N,S-Keteneacetals, and DMF

LR Wen, NN Man, WK Yuan, M Li - The Journal of Organic …, 2016 - ACS Publications
A concise and direct synthetic strategy for the construction of 2-aryliminochromene skeleton
by cascade three-component coupling reaction of arynes, N, S-keteneacetals, and DMF in …

Gold(III)-Catalyzed Tandem Reaction of Ketones with Phenols: Efficient and Highly Selective Synthesis of Functionalized 4H-Chromenes

Y Liu, J Qian, S Lou, J Zhu, Z Xu - The Journal of Organic …, 2010 - ACS Publications
Gold(III)-Catalyzed Tandem Reaction of Ketones with Phenols: Efficient and Highly Selective
Synthesis of Functionalized 4H-Chromenes | The Journal of Organic Chemistry ACS ACS …

Tyrosine kinase inhibitors

DM Goldstein - US Patent 8,962,831, 2015 - Google Patents
0 C* C. NC1= NC= Nc2c1C (C1= CC= CC= C1) CC2.[1*] C.[2*] C.[3*] C.[4*] C.[5*] C.[6*]
C.[7*] C.[Ar] Chemical compound C* C. NC1= NC= Nc2c1C (C1= CC= CC= C1) CC2.[1*] …

Water/Alkali-catalyzed reactions of azides with 2-cyanothioacetamides. eco-friendly synthesis of monocyclic and bicyclic 1, 2, 3-thiadiazole-4-carbimidamides and 5 …

VO Filimonov, LN Dianova, TV Beryozkina… - The Journal of …, 2019 - ACS Publications
The reactions of thioamides with azides in water were studied. It was reliably shown that the
reaction of 2-cyanothioacetamides 1 with various types of azides 2 in water in the presence …

Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors

DM Goldstein, KA Brameld - US Patent 9,376,438, 2016 - Google Patents
CO7D 487/04(2006.01)(I) and pharmaceutically acceptable salts that are tyrosine A
6LX3/59(2006.01) kinase inhibitors, in particular BLK, BMX, EGFR, HER2 …

New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure–activity relationships

F Areias, M Costa, M Castro, J Brea… - European journal of …, 2012 - Elsevier
In silico screening of a collection of 1584 academic compounds identified a small molecule
hit for the human adenosine A2A receptor (pKi= 6.2) containing a novel chromene scaffold …