Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

Angiogenesis is a multi-stage process of new blood vessel development from pre-existing
vessels toward an angiogenic stimulus. The process is essential for tissue maintenance and …

HIFs have long been associated with resistance to therapy, metastasis, and poor survival
rates in cancer patients. In parallel, although the tumor-suppressor p53 acts as the first …

Astragalus membranaceus Bunge is widely used in Traditional Chinese Medicine to treat
various cancers. Astragaloside-IV (AS-IV) is one of the major compounds isolated from A …

Introduction Anlotinib (AL3818) is a novel multi-target tyrosine kinase inhibitor (TKI) targeting
vascular endothelial growth factor receptor (VEGFR) and suppressing tumor growth …

Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas
(CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal …

Tumor microenvironments (TMEs) have received increasing attention in recent years as they
play pivotal roles in tumorigenesis, progression, metastases, and resistance to the traditional …

The Warburg effect is a prominent metabolic feature associated with neoplastic diseases;
however, the underlying mechanism remains incompletely understood. TAp73, a structural …

The low survival rate of esophageal squamous cell carcinoma patients is primarily attributed
to technical limitations and a lack of insight regarding the molecular mechanisms …