Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

[HTML][HTML] Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors with special emphasis on oxadiazoles as potent anti-diabetic agents

BD Mohammad, MS Baig, N Bhandari, FA Siddiqui… - Molecules, 2022 - mdpi.com
Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat
type 2 diabetes mellitus (T2DM). They may be combined with other medications as an …

Design, synthesis, characterization, molecular docking studies and anticancer activity evaluation of novel hydrazinecarbothioamide, 1, 2, 4-triazole-3-thione, 4 …

ED Dincel, Ç Akdağ, T Kayra, ED Coşar… - Journal of Molecular …, 2022 - Elsevier
A series of novel hydrazinecarbothioamide, 1, 2, 4-triazole-3-thione, 4-thiazolidinone and 1,
3, 4-oxadiazole derivatives were synthesized and evaluated for their cytotoxic activity …

[HTML][HTML] 1,3,4-Oxadiazole N-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities

LH Al-Wahaibi, AAB Mohamed, SS Tawfik, HM Hassan… - Molecules, 2021 - mdpi.com
The reaction of 5-(3, 4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2 (3 H)-thione 3 with
formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol …

Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4‐thiazolidinone and 1, 2, 4‐triazole‐3‐thione derivatives

ED Dincel, N Ulusoy‐Güzeldemirci… - Journal of …, 2021 - Wiley Online Library
A series of novel hydrazinecarbothioamide (5a, c, f), 4‐thiazolidinone (6a‐e), and 1, 2, 4‐
triazole‐3‐thione (7a‐d) were designed and synthesized. The structural elucidations of the …

Synthesis, molecular modeling investigation, molecular dynamic and ADME prediction of some novel Mannich bases derived from 1, 2, 4-triazole, and assessment of …

S Manap, H Medetalibeyoğlu, A Kılıç… - Journal of …, 2023 - Taylor & Francis
A series of biologically active novel Mannich bases containing with a 1 H-1, 2, 4-triazole-5-
one ring were developed to evaluate the cytotoxic activity. For this purpose, the synthesized …

[HTML][HTML] New 1, 3, 4-oxadiazole derivatives of pyridothiazine-1, 1-dioxide with anti-inflammatory activity

T Glomb, B Wiatrak, K Gębczak, T Gębarowski… - International Journal of …, 2020 - mdpi.com
Numerous studies have confirmed the coexistence of oxidative stress and inflammatory
processes. Long-term inflammation and oxidative stress may significantly affect the initiation …

Synthesis of novel Schiff bases and azol-β-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity …

YU Cebeci, H Bayrak, Y Şirin - Bioorganic chemistry, 2019 - Elsevier
In this study, new Schiff bases and β-lactam derivatives containing morpholine and thio
morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and …

Exploring the chemistry and therapeutic potential of triazoles: a comprehensive literature review

A Jain, P Piplani - Mini Reviews in Medicinal Chemistry, 2019 - ingentaconnect.com
Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological
properties, which could play a major role in the common mechanisms associated with …

[HTML][HTML] Efficient synthesis of magnetically separable CoFe2O4@ SiO2 nanoparticles and its potent catalytic applications for the synthesis of 5-aryl-1, 2, 4-triazolidine …

S Pansambal, S Ghotekar, S Shewale… - Journal of Water and …, 2019 - jwent.net
Magnetically separable silica-coated cobalt ferrite (CoFe2O4@ SiO2) magnetic
nanoparticles (MNPs) were synthesized by sol-gel auto combustion method. Silica matrix …