Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Dysfunction of the circadian rhythm is one of most common nonmotor symptoms in
Parkinson's disease (PD), but the molecular role of the circadian rhythm in PD is unclear. We …

Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and
the timing of biological systems to optimize physiology and behavior for the environmental …

Amyotrophic lateral sclerosis is a deleterious neurodegenerative disease without effective
treatment options. Recent studies have indicated the involvement of the dysregulation of …

Mounting evidence points to a role of the circadian clock in the temporal regulation of post-
transcriptional processes in mammals, including alternative splicing (AS). In this study, we …

Stress granule formation is important for stress response in normal cells and could lead to
chemotherapy resistance in cancer cells. Aberrant stress granule dynamics are also known …

Amyotropic lateral sclerosis (ALS) is a lethally progressive and irreversible
neurodegenerative disease marked by apparent death of motor neurons present in the …

Sleep is a highly intricate biological phenomenon, and its disorders play a pivotal role in
numerous diseases. However, the specific regulatory mechanisms remain elusive. In recent …

Gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5)
can cause high-bone-mass (HBM) phenotype, with 19 identified mutations so far. The A242T …