Prostate cancer is the second most frequent cancer diagnosis made in men and the fifth
leading cause of death worldwide. Prostate cancer may be asymptomatic at the early stage …

Prostate cancer is the second most common and fifth most aggressive neoplasm among
men worldwide. It is particularly incident in high human development index (HDI) nations …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

OBJECTIVE To identify published studies quantifying familial prostate cancer risks in
relatives of prostate cancer cases and, by meta‐analysis, obtain more precise estimates of …

Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations
are at increased risk of prostate cancer, particularly at an early age. To evaluate the …

It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis,
presence of phenocopies within high-risk pedigrees and genetic complexity. A genome …

Purpose: We review the current epidemiological and genetic knowledge regarding
hereditary prostate cancer, and outline its clinical implications. Materials and Methods …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …