Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …

Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-
dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas …

Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …

Cancer frequency and prevalence have been increasing in the past decades, with
devastating impacts on patients and their families. Despite the great advances in targeted …

Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the
angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …

Purpose PARP inhibitor resistance may be overcome by combinatorial strategies with
agents that disrupt homologous recombination repair (HRR). Multiple HRR pathway …

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in
promoting survival, virulence, and drug resistance across diverse pathogenic fungal …

Abstract HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …

Diseases are a manifestation of how thousands of proteins interact. In several diseases,
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …