Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature Reviews Drug Discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Benefits of zebrafish xenograft models in cancer research
X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …
Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1
Z Miao, W Tian, Y Ye, W Gu, Z Bao, L Xu, G Sun… - Cell death & …, 2022 - nature.com
Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-
dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas …
dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas …
Molecular chaperones in cancer stem cells: determinants of stemness and potential targets for antitumor therapy
A Kabakov, A Yakimova, O Matchuk - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …
Zebrafish avatars towards personalized medicine—a comparative review between avatar models
B Costa, MF Estrada, RV Mendes, R Fior - Cells, 2020 - mdpi.com
Cancer frequency and prevalence have been increasing in the past decades, with
devastating impacts on patients and their families. Despite the great advances in targeted …
devastating impacts on patients and their families. Despite the great advances in targeted …
Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression
H Wang, G Deng, M Ai, Z Xu, T Mou, J Yu, H Liu… - Oncogene, 2019 - nature.com
Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the
angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …
angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …
Combined PARP and HSP90 inhibition: preclinical and phase 1 evaluation in patients with advanced solid tumours
PA Konstantinopoulos, SC Cheng, JG Supko… - British journal of …, 2022 - nature.com
Purpose PARP inhibitor resistance may be overcome by combinatorial strategies with
agents that disrupt homologous recombination repair (HRR). Multiple HRR pathway …
agents that disrupt homologous recombination repair (HRR). Multiple HRR pathway …
Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors
DS Huang, EV LeBlanc… - Journal of medicinal …, 2019 - ACS Publications
The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in
promoting survival, virulence, and drug resistance across diverse pathogenic fungal …
promoting survival, virulence, and drug resistance across diverse pathogenic fungal …
Inhibitors of HSP90 in melanoma
A Mielczarek-Lewandowska, ML Hartman, M Czyz - Apoptosis, 2020 - Springer
Abstract HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
A Bolaender, D Zatorska, H He, S Joshi… - Nature …, 2021 - nature.com
Diseases are a manifestation of how thousands of proteins interact. In several diseases,
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …