Neuroblastoma: paradigm for precision medicine

MS Irwin, JR Park - Pediatric Clinics, 2015 - pediatric.theclinics.com
Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …

Neuroblastoma: molecular pathogenesis and therapy

CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …

Mutational dynamics between primary and relapse neuroblastomas

A Schramm, J Köster, Y Assenov, K Althoff, M Peifer… - Nature …, 2015 - nature.com
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often
lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression …

[HTML][HTML] Gene methylation in gastric cancer

Y Qu, S Dang, P Hou - Clinica chimica acta, 2013 - Elsevier
Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

Children's Oncology Group's 2013 blueprint for research: neuroblastoma

JR Park, R Bagatell, WB London… - Pediatric blood & …, 2013 - Wiley Online Library
Estimated 5‐year survival rates for patients with non‐high‐risk and high‐risk neuroblastoma
are 90% and 50%, respectively. Recent clinical trials have shown excellent outcomes with …

Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

AP Bracken, GL Brien, CP Verrijzer - Genes & development, 2019 - genesdev.cshlp.org
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …

Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities

DW Craig, JA O'Shaughnessy, JA Kiefer, J Aldrich… - Molecular cancer …, 2013 - AACR
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of
estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after …

The role of DNA methylation in cancer

R Lakshminarasimhan, G Liang - DNA Methyltransferases-Role and …, 2016 - Springer
The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

C Wang, Z Liu, CW Woo, Z Li, L Wang, JS Wei… - Cancer research, 2012 - AACR
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an
undifferentiated status and generally poor prognosis, but the basis for these characteristics …

Biological and genetic features of neuroblastoma and their clinical importance

N Aygun - Current pediatric reviews, 2018 - ingentaconnect.com
Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …