Neuroblastoma: paradigm for precision medicine
MS Irwin, JR Park - Pediatric Clinics, 2015 - pediatric.theclinics.com
Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …
Neuroblastoma: molecular pathogenesis and therapy
CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
Mutational dynamics between primary and relapse neuroblastomas
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often
lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression …
lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression …
[HTML][HTML] Gene methylation in gastric cancer
Y Qu, S Dang, P Hou - Clinica chimica acta, 2013 - Elsevier
Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …
Children's Oncology Group's 2013 blueprint for research: neuroblastoma
JR Park, R Bagatell, WB London… - Pediatric blood & …, 2013 - Wiley Online Library
Estimated 5‐year survival rates for patients with non‐high‐risk and high‐risk neuroblastoma
are 90% and 50%, respectively. Recent clinical trials have shown excellent outcomes with …
are 90% and 50%, respectively. Recent clinical trials have shown excellent outcomes with …
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …
remodelers and histone modifying enzymes are integral to the process of gene regulation …
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of
estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after …
estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after …
The role of DNA methylation in cancer
R Lakshminarasimhan, G Liang - DNA Methyltransferases-Role and …, 2016 - Springer
The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …
changes. With the advent of next-generation sequencing and large-scale multinational …
EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an
undifferentiated status and generally poor prognosis, but the basis for these characteristics …
undifferentiated status and generally poor prognosis, but the basis for these characteristics …
Biological and genetic features of neuroblastoma and their clinical importance
N Aygun - Current pediatric reviews, 2018 - ingentaconnect.com
Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …