A comprehensive review of SHP2 and its role in cancer

MD Asmamaw, XJ Shi, LR Zhang, HM Liu - Cellular Oncology, 2022 - Springer
Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

SHP2 sails from physiology to pathology

M Tajan, A de Rocca Serra, P Valet, T Edouard… - European journal of …, 2015 - Elsevier
Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor …

JM Chemnitz, RV Parry, KE Nichols… - The Journal of …, 2004 - journals.aai.org
To study the cis-and trans-acting factors that mediate programmed death 1 (PD-1) signaling
in primary human CD4 T cells, we constructed a chimeric molecule consisting of the murine …

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

M Tartaglia, EL Mehler, R Goldberg, G Zampino… - Nature …, 2001 - nature.com
Noonan syndrome (MIM 163950) is an autosomal dominant disorder characterized by
dysmorphic facial features, proportionate short stature and heart disease (most commonly …

[HTML][HTML] Crystal structure of the tyrosine phosphatase SHP-2

P Hof, S Pluskey, S Dhe-Paganon, MJ Eck… - Cell, 1998 - cell.com
The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 Å resolution, shows how
its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine …

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

M Tartaglia, K Kalidas, A Shaw, X Song… - The American Journal of …, 2002 - cell.com
Noonan syndrome (NS) is a developmental disorder characterized by facial dysmorphia,
short stature, cardiac defects, and skeletal malformations. We recently demonstrated that …

Activation of downstream signals by the long form of the leptin receptor

AS Banks, SM Davis, SH Bates, MG Myers - Journal of Biological Chemistry, 2000 - ASBMB
The adipocyte-derived hormone leptin signals the status of body energy stores by activating
the long form of the leptin receptor (LRb). Activation of LRb results in the activation of the …

Cytokine receptor signalling

JN Ihle - Nature, 1995 - nature.com
Many cell functions are regulated by members of the cytokine receptor superfamily.
Signalling by these receptors depends upon their association with Janus kinases (JAKs) …

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells

T Burdon, C Stracey, I Chambers, J Nichols… - Developmental …, 1999 - Elsevier
The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals
transduced through the cytokine receptor subunit gp130. Signalling molecules activated …

A family of proteins that inhibit signalling through tyrosine kinase receptors

A Kharitonenkov, Z Chen, I Sures, H Wang, J Schilling… - Nature, 1997 - nature.com
Phosphotyrosine phosphatases are critical negative or positive regulators in the intracellular
signalling pathways that result in growth-factor-specific cell responses such as mitosis …