Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

S Seal, G Dharmarajan, I Khan - Elife, 2021 - elifesciences.org
Researchers worldwide are repeatedly warning us against future zoonotic diseases
resulting from humankind's insurgence into natural ecosystems. The same zoonotic …

Common themes in zoonotic spillover and disease emergence: Lessons learned from bat-and rodent-borne RNA viruses

EP Williams, BM Spruill-Harrell, MK Taylor, J Lee… - Viruses, 2021 - mdpi.com
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest
percentage of living mammals on earth. Thus, it is not surprising that these two orders …

Strengthening a One Health approach to emerging zoonoses

S Mubareka, J Amuasi, A Banerjee, H Carabin… - Facets, 2023 - facetsjournal.com
Given the enormous global impact of the COVID-19 pandemic, outbreaks of highly
pathogenic avian influenza in Canada, and manifold other zoonotic pathogen activity, there …

Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea

AM Gamage, WOY Chan, F Zhu, YT Lim, S Long… - Immunity, 2022 - cell.com
Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-
cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs …

Landscape and age dynamics of immune cells in the Egyptian rousette bat

V Friedrichs, C Toussaint, A Schäfer, M Rissmann… - Cell Reports, 2022 - cell.com
Bats harbor high-impact zoonotic viruses often in the absence of disease manifestation. This
restriction and disease tolerance possibly rely on specific immunological features. In-depth …

Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats

SA Riesle-Sbarbaro, G Wibbelt, A Düx… - Nature …, 2024 - nature.com
The natural reservoir of Ebola virus (EBOV), agent of a zoonosis burdening several African
countries, remains unidentified, albeit evidence points towards bats. In contrast, the ecology …

Marburg virus persistence on fruit as a plausible route of bat to primate filovirus transmission

BR Amman, AJ Schuh, CG Albariño, JS Towner - Viruses, 2021 - mdpi.com
Marburg virus (MARV), the causative agent of Marburg virus disease, emerges sporadically
in sub-Saharan Africa and is often fatal in humas. The natural reservoir for this zoonotic virus …

Comparative analyses of bat genomes identify distinct evolution of immunity in Old World fruit bats

S Tian, J Zeng, H Jiao, D Zhang, L Zhang, C Lei… - Science …, 2023 - science.org
Bats have been identified as natural reservoir hosts of several zoonotic viruses, prompting
suggestions that they have unique immunological adaptations. Among bats, Old World fruit …

Robust evidence for bats as reservoir hosts is lacking in most African virus studies: a review and call to optimize sampling and conserve bats

N Weber, M Nagy, W Markotter, J Schaer… - Biology …, 2023 - royalsocietypublishing.org
Africa experiences frequent emerging disease outbreaks among humans, with bats often
proposed as zoonotic pathogen hosts. We comprehensively reviewed virus–bat findings …

Future trends in measuring physiology in free-living animals

HJ Williams, JR Shipley, C Rutz… - … of the Royal …, 2021 - royalsocietypublishing.org
Thus far, ecophysiology research has predominantly been conducted within controlled
laboratory-based environments, owing to a mismatch between the recording technologies …