Intratumoral heterogeneity in cancer progression and response to immunotherapy
Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …
The landscape of T cell antigens for cancer immunotherapy
The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …
[HTML][HTML] Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
F Wu, J Fan, Y He, A Xiong, J Yu, Y Li, Y Zhang… - Nature …, 2021 - nature.com
Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …
microenvironment together determine disease progression, as well as response to or …
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
D Hirschhorn, S Budhu, L Kraehenbuehl, M Gigoux… - Cell, 2023 - cell.com
Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because
tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple …
tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple …
[HTML][HTML] Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
PMK Westcott, F Muyas, H Hauck, OC Smith… - Nature Genetics, 2023 - nature.com
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
[HTML][HTML] Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …
Mechanisms of immune activation and regulation: lessons from melanoma
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …
particularly in terms of the immune response to tumours, and has been used as a model for …
[HTML][HTML] Colorectal cancer cells enter a diapause-like DTP state to survive chemotherapy
Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from
chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important …
chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important …
Lifileucel, a tumor-infiltrating lymphocyte therapy, in metastatic melanoma
AA Sarnaik, O Hamid, NI Khushalani… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Effective treatment options are limited for patients with advanced (metastatic or
unresectable) melanoma who progress after immune checkpoint inhibitors and targeted …
unresectable) melanoma who progress after immune checkpoint inhibitors and targeted …
Tumor mutational burden as a predictor of immunotherapy response: is more always better?
Immune checkpoint inhibitors, including antibodies that block programmed cell death protein-
1 (PD-1) and PD-L1, have transformed the management of many cancers. However, the …
1 (PD-1) and PD-L1, have transformed the management of many cancers. However, the …