Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Astrocytes in the initiation and progression of epilepsy
Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …
antiseizure medications, but seizure control is not achieved in approximately one-third of …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
Advances in the development of biomarkers for epilepsy
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
MicroRNA epigenetic signatures in human disease
K Piletič, T Kunej - Archives of toxicology, 2016 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …
MicroRNAs in epilepsy: pathophysiology and clinical utility
Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
GP Brennan, DC Henshall - Nature Reviews Neurology, 2020 - nature.com
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
[HTML][HTML] ATP and adenosine—Two players in the control of seizures and epilepsy development
Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
Precise detection of low-level somatic mutation in resected epilepsy brain tissue
Low-level somatic mutations have been shown to be the major genetic etiology of intractable
epilepsy. The extents thereof, however, have yet to be systematically and accurately …
epilepsy. The extents thereof, however, have yet to be systematically and accurately …
[HTML][HTML] Astrocyte-neuron circuits in epilepsy
The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …