Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro
FB Ntumngia, SK Kolli, P Annamalai Subramani… - Scientific Reports, 2024 - nature.com
In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite
invasion of erythrocytes and disease development. Very few studies have evaluated pre …
invasion of erythrocytes and disease development. Very few studies have evaluated pre …
Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates
J Nicholas, SL De, P Thawornpan… - PLoS Neglected …, 2023 - journals.plos.org
Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …
Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites
AA Ruberto, C Bourke, N Merienne, T Obadia… - Scientific reports, 2021 - nature.com
In the malaria-causing parasite's life cycle, Plasmodium sporozoites must travel from the
midgut of a mosquito to the salivary glands before they can infect a mammalian host …
midgut of a mosquito to the salivary glands before they can infect a mammalian host …
Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development
HN Bogale, TV Pascini, S Kanatani… - Proceedings of the …, 2021 - National Acad Sciences
Despite the critical role of Plasmodium sporozoites in malaria transmission, we still know
little about the mechanisms underlying their development in mosquitoes. Here, we use …
little about the mechanisms underlying their development in mosquitoes. Here, we use …
Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection
P Thawornpan, J Nicholas, C Malee… - PLoS Neglected …, 2024 - journals.plos.org
Background P. vivax malaria is a major global health burden hindering social and economic
development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) …
development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) …
A conserved Plasmodium structural integrity maintenance protein (SIMP) is associated with sporozoite membrane and is essential for maintaining shape and …
D Singh, S Patri, V Narahari… - Molecular …, 2022 - Wiley Online Library
Plasmodium sporozoites are extracellular forms introduced during mosquito bite that
selectively invade mammalian hepatocytes. Sporozoites are delimited by a cell membrane …
selectively invade mammalian hepatocytes. Sporozoites are delimited by a cell membrane …
Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites
To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages,
fourteen P. falciparum proteins were selected based on expression in sporozoites or their …
fourteen P. falciparum proteins were selected based on expression in sporozoites or their …
Preliminary Characterization and Functional Validation of Pre-Erythrocytic Vaccine Candidates for the Malaria Parasite Plasmodium vivax
JL Nicholas III - 2023 - search.proquest.com
Abstract RTS, S/AS01, vaccine targeting malaria caused by Plasmodium falciparum, used in
moderate to high malaria transmission, provides hope for pre-erythrocytic (PE) subunit …
moderate to high malaria transmission, provides hope for pre-erythrocytic (PE) subunit …