Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain
studies have historically excluded females as research subjects. Male-biased explanations …

Neuropathic pain (NP) resulting from a lesion or disease of the somatosensory system can
lead to loss of function and reduced life quality. Neuroinflammation plays a vital role in the …

Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset
joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric …

Paclitaxel is widely used in the treatment of various types of solid malignancies. Paclitaxel-
induced peripheral neuropathy (PIPN) is often characterized by burning pain, cold, and …

Simple Summary Paclitaxel, a drug used in the treatment of malignancies such as lung,
ovarian and breast cancer, often produces severe side effects, among which is peripheral …

Background Management of pain post-surgery is crucial for tissue healing in both veterinary
and human medicine. Overuse of some analgesics such as opioids may lead to addictions …

Paclitaxel is a chemotherapy drug widely used for the treatment of various cancers based on
its ability to potently stabilize cellular microtubules and block division in cancer cells …

PEGPH20, a human recombinant hyaluronidase, has been proposed as a coadjutant to
pancreatic cancer chemotherapy. In early trials, patients reported increased widespread …

Introduction Surgical interventions in mice require appropriate pain relief to ensure animal
welfare and to avoid influence of pain on research findings. Carprofen is a non-steroidal anti …

Patients treated with cancer chemotherapeutics frequently report chemotherapy-induced
peripheral neuropathy (CIPN), changes in mood (depression and anxiety) and functional …