The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Chemoresistance to platinum‑based chemotherapy for ovarian cancer in the advanced
stage remains a formidable concern clinically. Increasing evidence has revealed that …

Ebselen is a glutathione (GSH) peroxidase (GPx) mimic originally developed to reduce
reactive oxygen species (ROS). However, little is known about its cytotoxicological effects on …

In this review we have showcased the preclinical development of original amphiphilic
nanomaterials designed for ruthenium-based anticancer treatments, to be placed within the …

Standardized treatment guidelines and effective drugs are not available for human triple-
negative breast cancer (TNBC). Many efforts have recently been exerted to investigate the …

Background: Pseudorabies virus (PRV) infection induces apoptosis in swine cells both in
vitro and in vivo; however, the mechanism associated with host-cell signaling has not been …

Auranofin, an inhibitor of thioredoxin reductase (TrxR), inhibits the growth of a variety of
cancer cells. In the present study, various lung cancer cells were used to investigate the …

Natural compounds, such as paclitaxel and camptothecin, have great effects on the
treatment of tumors. Such natural chemicals often achieve anti-tumor effects through a …

Antiapoptotic members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins are one of
the overexpressed proteins in cancer cells that are oncogenic targets. As such, targeting of …

Abstract Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-1-oxyl) is a potential redox agent
in cells. The present study investigated changes in cellular reactive oxygen species (ROS) …