[HTML][HTML] DNA and histone methylation in gastric carcinogenesis

DQ Calcagno, CO Gigek, ES Chen… - World journal of …, 2013 - ncbi.nlm.nih.gov
Epigenetic alterations contribute significantly to the development and progression of gastric
cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the …

Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation

Z Herceg, MP Lambert, K van Veldhoven… - …, 2013 - academic.oup.com
Remarkable progress in the field of epigenetics has turned academic, medical and public
attention to the potential applications of these new advances in medicine and various fields …

[HTML][HTML] Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense

J Jantsch, V Schatz, D Friedrich, A Schröder, C Kopp… - Cell metabolism, 2015 - cell.com
Immune cells regulate a hypertonic microenvironment in the skin; however, the biological
advantage of increased skin Na+ concentrations is unknown. We found that Na+ …

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine

M Stein, P Ruggiero, R Rappuoli, F Bagnoli - Frontiers in immunology, 2013 - frontiersin.org
Helicobacter pylori colonizes the gastric mucosa of more than 50% of the human population,
causing chronic inflammation, which however is largely asymptomatic. Nevertheless, H …

The immune battle against Helicobacter pylori infection: NO offense

AP Gobert, KT Wilson - Trends in microbiology, 2016 - cell.com
Helicobacter pylori is a successful pathogen of the human stomach. Despite a vigorous
immune response by the gastric mucosa, the bacterium survives in its ecological niche, thus …

LPS-induced histone H3 phospho (Ser10)-acetylation (Lys14) regulates neuronal and microglial neuroinflammatory response

G Rigillo, A Vilella, C Benatti, L Schaeffer… - Brain, behavior, and …, 2018 - Elsevier
Epigenetic modifications of DNA and histone proteins are emerging as fundamental
mechanisms by which neural cells adapt their transcriptional response to environmental …

Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies

J Zeng, C Xie, L Zhang, X Liu, MTV Chan… - International Journal of …, 2022 - mdpi.com
The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly
associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics …

The enterochromaffin-like [ECL] cell—Central in gastric physiology and pathology

HL Waldum, ØF Sørdal, PG Mjønes - International Journal of Molecular …, 2019 - mdpi.com
Background: Studies on the regulation of gastric and pancreatic secretion began more than
100 years ago. Secretin was the first hormone postulated to exist, initiating the field of …

Influences of lysine‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) …

J Yuan, R Que, W Zhao, F Song… - Journal of Applied …, 2023 - Wiley Online Library
Abstract Lysine‐specific demethylase 1 (LSD1) inhibitors are being developed for cancer
therapy, but their bioeffects on vasculatures are not clear. In this study, we compared the …

Linking immunity, epigenetics, and cancer in inflammatory bowel disease

J Däbritz, TR Menheniott - Inflammatory bowel diseases, 2014 - academic.oup.com
Most of what is known about the pathogenesis of inflammatory bowel disease (IBD) pertains
to complex interplay between host genetics, immunity, and environmental factors. Epigenetic …