Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely
studied in various types of cancers. ROS are considered to be normal byproducts of …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Hypercholesterolemia and dyslipidemia are associated with an increased risk for many
cancer types and with poor outcomes in patients with established disease. Whereas the …

BACKGROUND Metabolic reprogramming is a hallmark of malignancy first recognized a
century ago. In some cases, reprogrammed metabolic activities can be exploited to …

The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …