Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Perinatal exposure to Δ 9-tetrahydrocannabinol (THC) affects brain development and might
increase the incidence of psychopathology later in life, which seems to be related to a …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …

Abstract Histone deacetylases 3 (HDAC3) modulates the acetylation state of histone and
non‐histone proteins and could be a powerful regulator of the inflammatory process in …

The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological
tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Schizophrenia (SCZ) is a serious psychiatric condition with a 1% lifetime risk. SCZ is one of
the top ten global causes of disabilities. Despite numerous attempts to understand the …

In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure
of rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 …

Differentiation therapy using small molecules is a promising strategy for improving the
prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate …