A comparison of chromosomal anomalies detected in 30 cases of breast cancer in females
with near-diploid karyotypes is reported. The tumors, of which 20 were previously …

The integration of transfected plasmid DNA at the telomere of chromosome 13 in an
immortalized simian virus 40‐transformed human cell line provided the first opportunity to …

The G-overhangs of telomeres are thought to adopt particular conformations, such as T-
loops or G-quadruplexes. It has been suggested that G-quadruplex structures could be …

Telomerase represents a relevant target for cancer therapy. Molecules able to stabilize the G-
quadruplex (G4), a structure adopted by the 3′-overhang of telomeres, are thought to …

A simple method for the harvest of bladder cell types from surgical specimens was used to
generate strains of normal human urothelial cells that could be reproducibly cultivated …

Amplification of the epidermal growth factor receptor gene on double minutes is recurrently
observed in cells of advanced gliomas, but the structure of these extrachromosomal circular …

Spontaneous telomere loss has been proposed as an important mechanism for initiating the
chromosome instability commonly found in cancer cells. We have previously shown that …

The development of genomic instability is an important step in generatingthe multiple
genetic changes required for cancer. One consequence of genomic instability is the …

The activity of superoxide dismutases (SOD) I and 2 was analysed in correlation with mRNA
and chromosome content in 6 SV40‐transformed (TF) and in non‐transformed (NF) human …

Reversible transcriptional silencing of genes located near telomeres, termed the telomere
position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been …