Background: In preconception and pregnancy, women are encouraged to take folic acid-
based supplements over and above food intake. The upper tolerable limit of folic acid is …

Nonobstructive azoospermia (NOA) represents the most severe expression of male infertility,
involving around 1% of the male population and 10% of infertile men. This condition is …

Purpose: To evaluate the effect of folate and folate plus zinc supplementation on endocrine
parameters and sperm characteristics in sub fertile men. Materials and Methods: We …

Background and Objectives Methylenetetrahydrofolate reductase (MTHFR) polymorphism
may be a risk factor for male infertility. However, the epidemiologic studies showed …

Infertility affects nearly 50 million couples worldwide, with 40− 50% of cases having a male
factor component. It is well established that nutritional status impacts reproductive …

The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key
enzymes in folate metabolism. This gene is located on chromosome 1 (1p36. 3), which has …

Several studies showed that the genetic mutations in the folate-related enzyme genes might
be associated with male infertility; however, the results were still inconsistent. We performed …

Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in
folate metabolism. The association of MTHFR gene Ala222Val polymorphism with male …

This study reports, for the first time, the significant (p≤ 0.01) accumulation of homocysteine
residues in low density, defective sperm suspensions isolated from patients attending an …

Infertility occurs in 15% of couples. Half of the causes of infertility are related to male factors
Furthermore; about 15-30% of these male factors are related to genetic factors ( 1). Defects …