Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease. The
maternal symptoms are characterized by skin pruritus and elevated bile acids, causing …

Highlights•Cholestatic liver diseases and bile acid homeostasis are closely
connected.•Numerous signaling molecules are associated with bile acid transporters, tight …

В настоящем издании проанализированы и систематизированы сведения по
клиническому применению лекарственных средств, для которых гепатотропное …

Ursodeoxycholic acid (UDCA), first identified in bear bile, was widely used in cholestatic
liver diseases. Our previous studies have suggested UDCA may exert favorable influence …

Epidemiological data show that chronic stress has adverse effects on the incidence and
progression of cancer. As a critical target organ for stress hormones, the stomach is …

Berberine is a natural plant alkaloid isolated from a diverse range of genera, it obtains anti-
inflammatory, anti-obesity, and hepatoprotective properties, and is a promising agent for non …

Bile acid metabolism in aquatic animals usually is suppressed when fish meal (FM) is
replaced by plant proteins. An eight weeks feeding experiment was conducted to evaluate …

The accumulation of bile acids in the liver leads to the development of cholestasis and
hepatocyte injury. Nuclear receptors control the synthesis and transport of bile acids in the …

Autophagy is a lysosomal degradation pathway in which the cell self-digests its own
components to provide nutrients in harsh environmental conditions. It also represents an …

Nutritional diarrhea and subsequent performance degradation in weaned piglets are major
challenges for the pig industry. Bile acids (BA) can be added to the diet as emulsifiers. This …