Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

The generation of carbon radicals by halogen-atom and group transfer reactions is generally
achieved using tin and silicon reagents that maximize the interplay of enthalpic …

Abstract Histone deacetylase 3 (HDAC3) is an epigenetic regulator that involves gene
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …

Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics
that ensure the somatic inheritance of differentiated state is defined as a crucial factor …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …