New technologies are permitting large-scale quantitative studies of signal-transduction
networks. Such data are hard to understand completely by inspection and intuition.'Data …

The advancements in “omics”(proteomics, genomics, lipidomics, and metabolomics)
technologies have yielded large inventories of genes, transcripts, proteins, and metabolites …

Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …

Immunoblotting (also known as Western blotting) combined with digital image analysis can
be a reliable method for analyzing the abundance of proteins and protein modifications, but …

Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to
survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also …

The identification and validation of drug targets are crucial in biomedical research and many
studies have been conducted on analyzing drug target features for getting a better …

New methods to quantify protein kinase activities directly from complex cellular mixtures are
critical for understanding biological regulatory pathways. Herein, a fluorescence-based …

Tumor necrosis factor (TNF) is a proinflammatory cytokine that induces conflicting pro-and
antiapoptotic signals whose relative strengths determine the extent of cell death. TNF …

To more effectively target complex diseases like cancer, diabetes and schizophrenia, we
may need to rethink our strategies for drug development and the selection of molecular …