T‐cell receptor binding affinities and kinetics: impact on T‐cell activity and specificity
The interaction between the T‐cell receptor (TCR) and its peptide–major histocompatibility
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …
Engineering strategies to enhance TCR-based adoptive T cell therapy
JA Rath, C Arber - Cells, 2020 - mdpi.com
T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the
treatment of cancer, as TCRs can cover a broad range of target antigens. Here we …
treatment of cancer, as TCRs can cover a broad range of target antigens. Here we …
Tracking epitope-specific T cells
The tracking of antigen-specific T cells in vivo is a useful approach for the study of the
adaptive immune response. This protocol describes how populations of T cells specific for a …
adaptive immune response. This protocol describes how populations of T cells specific for a …
Capture agents and related methods and systems for detecting and/or sorting targets
Polynucleotide-encoded capture agents for target detection and in particular modular
polynucleotide-capture agents comprising a target binding component, a scaffold compo …
polynucleotide-capture agents comprising a target binding component, a scaffold compo …
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects
H Reijonen, EJ Novak, S Kochik, A Heninger… - Diabetes, 2002 - Am Diabetes Assoc
Soluble HLA-DR401 or-DR404 tetramers containing a peptide corresponding to an
immunodominant epitope from human GAD65 were used to analyze peripheral blood T …
immunodominant epitope from human GAD65 were used to analyze peripheral blood T …
Class II major histocompatibility complex tetramer staining: progress, problems, and prospects
SS Vollers, LJ Stern - Immunology, 2008 - Wiley Online Library
The use of major histocompatibility complex (MHC) tetramers in the detection and analysis
of antigen‐specific T cells has become more widespread since its introduction 11 years ago …
of antigen‐specific T cells has become more widespread since its introduction 11 years ago …
Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy
Abstract Helper (CD4+) T cells perform direct therapeutic functions and augment responses
of cells such as cytotoxic (CD8+) T cells against a wide variety of diseases and pathogens …
of cells such as cytotoxic (CD8+) T cells against a wide variety of diseases and pathogens …
Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells
The human immune system consists of a large number of T cells capable of recognizing and
responding to antigens derived from various sources. The development of peptide-major …
responding to antigens derived from various sources. The development of peptide-major …
Quantitative challenges in understanding ligand discrimination by αβ T cells
O Feinerman, RN Germain, G Altan-Bonnet - Molecular immunology, 2008 - Elsevier
To fight viral or bacterial infections effectively without endangering their own viability,
vertebrate organisms rely on the ability of their adaptive immune system to distinguish self …
vertebrate organisms rely on the ability of their adaptive immune system to distinguish self …
Identification of type II collagen peptide 261–273‐specific T cell clones in a patient with relapsing polychondritis
JH Buckner, M Van Landeghen, WW Kwok… - Arthritis & …, 2002 - Wiley Online Library
Objective To characterize and clone T cells specific for type II collagen (CII) in a patient with
relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII …
relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII …