The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Breast cancer (BC) is one of the most prevalent cancers in women. Triple-negative breast
cancer (TNBC) in which the three major receptors ie estrogen receptor (ER), progesterone …

Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Paclitaxel (PTX) and docetaxel (DTX) are key members of taxanes with high anti-tumor
activity against various cancer cells. These chemotherapeutic agents suffer from a number of …

The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability,
gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus …

Background The oral route is the most popular route for the clinical administration of drugs to
treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo …

The oral delivery of anti-cancer agents is typically challenging due to low bioavailability and
significant gastrointestinal side effects of drugs. Docetaxel is a lipophilic anti-cancer agent …

This study aimed to develop and optimize a self-nanoemulsifying drug delivery system
(SNEDDS) of bosentan (BOS) to solve its poor oral bioavailability due to low water solubility …