Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes

JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Astrocytic modulation of neuronal signalling

SS Purushotham, Y Buskila - Frontiers in Network Physiology, 2023 - frontiersin.org
Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

A concerted neuron–astrocyte program declines in ageing and schizophrenia

E Ling, J Nemesh, M Goldman, N Kamitaki, N Reed… - Nature, 2024 - nature.com
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions

A Baudon, EC Creusot, F Althammer, CP Schaaf… - Progress in …, 2022 - Elsevier
The neuropeptide oxytocin has been in the focus of scientists for decades due to its
profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors …

Primary cilia signaling in astrocytes mediates development and regional-specific functional specification

L Wang, Q Guo, S Acharya, X Zheng, V Huynh… - Nature …, 2024 - nature.com
Astrocyte diversity is greatly influenced by local environmental modulation. Here we report
that the majority of astrocytes across the mouse brain possess a singular primary cilium …

Reactive astrocytes and emerging roles in central nervous system (CNS) disorders

SA Liddelow, ML Olsen… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
In addition to their many functions in the healthy central nervous system (CNS), astrocytes
respond to CNS damage and disease through a process called “reactivity.” Recent evidence …

Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Curcumin modulates astrocyte function under basal and inflammatory conditions

M Seady, FT Fróes, CA Gonçalves, MC Leite - Brain Research, 2023 - Elsevier
Curcumin is a pleiotropic molecule with well-known anti-inflammatory effects. This molecule
has attracted attention due to its capacity to pass the blood–brain–barrier and modulate …

Astrocytes in memory formation and maintenance

K Bohmbach, C Henneberger… - Essays in …, 2023 - portlandpress.com
Learning and memory are fundamental but highly complex functions of the brain. They rely
on multiple mechanisms including the processing of sensory information, memory formation …

Experience-dependent glial pruning of synaptic glomeruli during the critical period

N Nelson, DJ Vita, K Broadie - Scientific Reports, 2024 - nature.com
Critical periods are temporally-restricted, early-life windows when sensory experience
remodels synaptic connectivity to optimize environmental input. In the Drosophila juvenile …