Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Fragment-based drug (or lead) discovery (FBDD or FBLD) has developed in the last two
decades to become a successful key technology in the pharmaceutical industry for early …

Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …

Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

The current version of the androgen receptor gene (AR) mutations database is described. A
major change to the database is that the nomenclature and numbering scheme now …

The standard systemic treatment for prostate cancer (PCa) is androgen ablation, which
causes tumor regression by inhibiting activity of the androgen receptor (AR). Invariably, PCa …

Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules.
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …

Androgen insensitivity syndrome in its complete form is a disorder of hormone resistance
characterised by a female phenotype in an individual with an XY karyotype and testes …