Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Toxoplasma Effectors Targeting Host Signaling and Transcription

MA Hakimi, P Olias, LD Sibley - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

The pathogenicity and virulence of Toxoplasma gondii

SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Z Huang, H Liu, J Nix, R Xu, CR Knoverek… - Nature …, 2022 - nature.com
Signal transducer and activator of transcription (STAT) proteins communicate from cell-
surface receptors to drive transcription of immune response genes. The parasite …

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

ND Marino, MW Panas, M Franco, TC Theisen… - PLoS …, 2018 - journals.plos.org
Toxoplasma gondii is an obligate intracellular parasite that can infect virtually all nucleated
cells in warm-blooded animals. The ability of Toxoplasma tachyzoites to infect and …

Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways

N Mammari, MA Halabi, S Yaacoub… - BioMed research …, 2019 - Wiley Online Library
Infection with Toxoplasma gondii has a major implication in public health. Toxoplasma
gondii is an obligate intracellular protozoan parasite that can infect all nucleated cells …

Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity

HL Mercer, LM Snyder, CM Doherty, BA Fox… - PLoS …, 2020 - journals.plos.org
The apicomplexan Toxoplasma gondii induces strong protective immunity dependent upon
recognition by Toll-like receptors (TLR) 11 and 12 operating in conjunction with MyD88 in …

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

Y Wang, LO Sangaré… - Annual review of …, 2020 - annualreviews.org
Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live
inside a vacuole that resides in the host cytosol. Vacuolar residence provides these …

Transport mechanisms at the malaria parasite-host cell interface

JR Beck, CM Ho - PLoS Pathogens, 2021 - journals.plos.org
Obligate intracellular malaria parasites reside within a vacuolar compartment generated
during invasion which is the principal interface between pathogen and host. To subvert their …

Seizing control: How dense granule effector proteins enable Toxoplasma to take charge

MW Panas, JC Boothroyd - Molecular microbiology, 2021 - Wiley Online Library
Control of the host cell is crucial to the Apicomplexan parasite, Toxoplasma gondii, while it
grows intracellularly. To achieve this goal, these single‐celled eukaryotes export a series of …