Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary
research activities. With the recent megatrend of digitalization sweeping across all …

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and
peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

Oxidative stress is a crucial concept in redox biology, and significant progress has been
made in recent years. Excessive levels of reactive oxygen species (ROS) can lead to …

Red fluorescent protein (RFP) derived indicators are popular due to advantages such as
increased imaging depth and reduced autofluorescence and cytotoxicity. However, most …

The inter-relationship between microglia dynamics and oxidative stress (Ox-stress) in
dystrophic neurites (DNs) at Alzheimer's Disease (AD) plaques may contribute to the …