Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology …
Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …
prevention, and treatment of human prostate cancer. While tissue culture models are …
Translational models of prostate cancer bone metastasis
Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …
accurately recapitulate the spread of prostate cancer to bone—the most common site of …
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
Z Ding, CJ Wu, GC Chu, Y Xiao, D Ho, J Zhang… - Nature, 2011 - nature.com
Effective clinical management of prostate cancer (PCA) has been challenged by significant
intratumoural heterogeneity on the genomic and pathological levels and limited …
intratumoural heterogeneity on the genomic and pathological levels and limited …
[HTML][HTML] Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …
Mouse models of prostate cancer: picking the best model for the question
MM Grabowska, DJ DeGraff, X Yu, RJ Jin… - Cancer and Metastasis …, 2014 - Springer
Abstract When the National Institutes of Health Mouse Models of Human Cancer Consortium
initiated the Prostate Steering Committee 15 years ago, there were no genetically …
initiated the Prostate Steering Committee 15 years ago, there were no genetically …
Mouse models of prostate cancer
KC Valkenburg, BO Williams - Prostate cancer, 2011 - Wiley Online Library
The development and optimization of high‐throughput screening methods has identified a
multitude of genetic changes associated with human disease. The use of immunodeficient …
multitude of genetic changes associated with human disease. The use of immunodeficient …
How genetically engineered mouse tumor models provide insights into human cancers
K Politi, W Pao - Journal of clinical oncology, 2011 - ascopubs.org
Genetically engineered mouse models (GEMMs) of human cancer were first created nearly
30 years ago. These early transgenic models demonstrated that mouse cells could be …
30 years ago. These early transgenic models demonstrated that mouse cells could be …
Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer
M Stentenbach, JA Ermer, DL Rudler… - EMBO Molecular …, 2023 - embopress.org
Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of
cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; …
cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; …
Modeling prostate cancer in mice: limitations and opportunities
PJ Hensley, N Kyprianou - Journal of andrology, 2012 - Wiley Online Library
The complex dynamics of the tumor microenvironment and prostate cancer heterogeneity
have confounded efforts to establish suitable preclinical mouse models to represent human …
have confounded efforts to establish suitable preclinical mouse models to represent human …
[HTML][HTML] Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways
The ATBF1/ZFHX3 gene at 16q22 is the second most frequently mutated gene in human
prostate cancer and has reduced expression or mislocalization in several types of human …
prostate cancer and has reduced expression or mislocalization in several types of human …