The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options
Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …
Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …
tDCS-induced modulation of GABA concentration and dopamine release in the human brain: A combination study of magnetic resonance spectroscopy and positron …
T Bunai, T Hirosawa, M Kikuchi, M Fukai, M Yokokura… - Brain stimulation, 2021 - Elsevier
Background Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal
cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting …
cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting …
GABAergic changes in the thalamocortical circuit in Parkinson's disease
AJM van Nuland, HEM den Ouden, H Zach… - Human Brain …, 2020 - Wiley Online Library
Parkinson's disease is characterized by bradykinesia, rigidity, and tremor. These symptoms
have been related to an increased gamma‐aminobutyric acid (GABA) ergic inhibitory drive …
have been related to an increased gamma‐aminobutyric acid (GABA) ergic inhibitory drive …
[HTML][HTML] Antiparkinsonian effects of polyphenols: a narrative review with a focus on the modulation of the gut-brain axis
W Zhang, X Dong, R Huang - Pharmacological Research, 2023 - Elsevier
Polyphenols, which are naturally occurring bioactive compounds in fruits and vegetables,
are emerging as potential therapeutics for neurological disorders such as Parkinson's …
are emerging as potential therapeutics for neurological disorders such as Parkinson's …
Multi-vendor standardized sequence for edited magnetic resonance spectroscopy
Spectral editing allows direct measurement of low-concentration metabolites, such as GABA,
glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho) physiology …
glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho) physiology …
Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis
JD Braga, M Thongngam, T Kumrungsee - npj Science of Food, 2024 - nature.com
Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an
inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with …
inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with …
[HTML][HTML] Exercise protects synaptic density in a rat model of Parkinson's disease
KH Binda, TP Lillethorup, CC Real, SL Bærentzen… - Experimental …, 2021 - Elsevier
Background Parkinson's disease (PD) is characterized by Lewy body and neurite pathology
associated with dopamine terminal dysfunction. Clinically, it is associated with motor …
associated with dopamine terminal dysfunction. Clinically, it is associated with motor …
[HTML][HTML] Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study
A Bullock, I Kaul, S Li, C Silber, J Doherty… - Journal of the …, 2021 - Elsevier
Parkinson's disease (PD) is characterized by both motor and nonmotor deficits. Among
cardinal symptoms of this disorder, tremor is the least responsive to dopamine replacement …
cardinal symptoms of this disorder, tremor is the least responsive to dopamine replacement …
[HTML][HTML] Using Caenorhabditis elegans to model therapeutic interventions of neurodegenerative diseases targeting microbe-host interactions
Emerging evidence from both clinical studies and animal models indicates the importance of
the interaction between the gut microbiome and the brain in the pathogenesis of …
the interaction between the gut microbiome and the brain in the pathogenesis of …