Coronavirus vaccine development: from SARS and MERS to COVID-19

YD Li, WY Chi, JH Su, L Ferrall, CF Hung… - Journal of biomedical …, 2020 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of
coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the …

The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies

LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

LE Escobar, A Molina-Cruz… - Proceedings of the …, 2020 - National Acad Sciences
A series of epidemiological explorations has suggested a negative association between
national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and …

BCG-induced trained immunity: can it offer protection against COVID-19?

LAJ O'Neill, MG Netea - Nature Reviews Immunology, 2020 - nature.com
Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to
respiratory tract infections, an effect proposed to be mediated by the general long-term …

Trained immunity: reprogramming innate immunity in health and disease

S Bekkering, J Domínguez-Andrés… - Annual review of …, 2021 - annualreviews.org
Traditionally, the innate and adaptive immune systems are differentiated by their specificity
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …

[HTML][HTML] Non-specific effects of BCG vaccine on viral infections

S Moorlag, RJW Arts, R Van Crevel… - Clinical microbiology and …, 2019 - Elsevier
Abstract Background Some strains of Bacillus Calmette–Guérin (BCG) vaccine not only
confer protection against disseminated forms of tuberculosis, but also reduce all-cause …

BCG-induced cross-protection and development of trained immunity: implication for vaccine design

C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

S Prentice, B Nassanga, EL Webb, F Akello… - The Lancet Infectious …, 2021 - thelancet.com
Background Trials done in infants with low birthweight in west Africa suggest that BCG
vaccination reduces all-cause mortality in the neonatal period, probably because of …

[HTML][HTML] Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines

WG Dos Santos - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) continues to challenge most scientists in the
search of an effective way to either prevent infection or to avoid spreading of the disease. As …

Sex-based differences in immune function and responses to vaccination

SL Klein, I Marriott, EN Fish - … of the Royal Society of Tropical …, 2015 - academic.oup.com
Females typically develop higher antibody responses and experience more adverse
reactions following vaccination than males. These differences are observed in response to …